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An agonist of the bile acid receptor TGR5 (EC50 = 1 µM) and blocks fatty liver development in cells and mice given ethanol; reduces NF-κB signaling and expression of miR-33 in LPS-treated macrophages, increasing levels of ABCA1; inhibits replication of HIV-1 (IC50 = 1.4 µM) and has cytotoxic effects against cancer cells
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Tumour Necrosis Factor alpha (TNF alpha) is a potent pro-inflammatory cytokine[1] TNF alpha binds to its receptors mainly TNFR1 and TNFR2 and then transmits molecular signals for biological functions such as inflammation and cell death[2] TNF alpha stimulates NF- B pathway via TNFR2 promotes cancer growth invasion and metastasis Anti-TNF- MAb significantly suppresses the tumor development in colitis-associated cancer (CAC) mouse[3] TNF alpha as a proneurogenic factor activates the SAPK/JNK Pathway and can facilitate neuronal replacement and brain repair in response to brain injury[4] TNF-alpha/TNFSF2 Protein Cynomolgus (Biotinylated) is a biotinylated recombinant protein consisting of 157 amino acids (V77-L233) and is produced in E coli
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